BOC-3-AMINOBENZYLALCOHOL Chemical Properties

Melting point:

98 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))

Boiling point:

309.3±25.0 °C(Predicted)

Density 

1.161±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

13.71±0.70(Predicted)

BOC-3-AMINOBENZYLALCOHOL Usage And Synthesis

Synthesis

Synthesis of Compound 14A: 3-Aminobenzyl alcohol (3 g, 24.36 mmol, 1.00 eq.) was dissolved in tetrahydrofuran (60 mL) followed by addition of di-tert-butyl dicarbonate (6.38 g, 29.23 mmol, 1.20 eq.). The reaction mixture was stirred at room temperature overnight and then diluted with 200 mL of water. It was extracted three times with ethyl acetate (100 mL), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a yellow oily crude product (13.85 g, compound 14A).

References

[1] Patent: WO2016/134450, 2016, A1. Location in patent: Page/Page column 92-93
[2] Patent: WO2017/210471, 2017, A1. Location in patent: Paragraph 0011336; 001137
[3] Patent: US2008/21032, 2008, A1. Location in patent: Page/Page column 56
[4] Patent: US2018/312497, 2018, A1. Location in patent: Paragraph 0066; 0121
[5] Patent: US2012/94997, 2012, A1. Location in patent: Page/Page column 104-105

BOC-3-AMINOBENZYLALCOHOL(118684-31-4)Related Product Information

• BOC-3-AMINOBENZOIC ACID
• 3-AMINO-5-CARBOXYBENZENEBORONIC ACID, N-BOC PROTECTED 98
• BOC-5-AMINO-2-METHOXYBENZOIC ACID
• N-BOC-3-AMINO-4-CHLOROBENZOIC ACID
• BOC-3-AMINO-2-METHYLBENZOIC ACID
• BOC-2-AMINOBENZENE-1,4-DICARBOXYLIC ACID
• 3,5-BIS-BOC-AMINOBENZOIC ACID
• DI-BOC-3,4-DIAMINOBENZOIC ACID
• TERT-BUTYL N-[3-(2-METHYL-1,3-DIOXOLAN-2-YL)PHENYL]CARBAMATE
• 3-(BOC-AMINO)-4-HYDROXYBENZOIC ACID
• BOC-3-AMINOBENZYLALCOHOL
• Benzoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-methoxy- (9CI)
• BOC-3-AMINO-4-METHYLBENZOIC ACID
• BOC-3-AMINOBENZENE-1,2-DICARBOXYLIC ACID
• BOC-3-AMINO-5-(FMOC-AMINO)-BENZOIC ACID
• N-BOC-5-AMINO-2-CHLOROBENZOIC ACID
• 3-[(tert-Butoxycarbonyl)amino]-5-hydroxybenzoic acid
• 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID