H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH
H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH Basic information
- Product Name:
- H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH
- Synonyms:
-
- DL-ISOSER-PHE-LEU-LEU-ARG-ASN
- H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH
- ISO-TRAP
- iso-TRAP, (DL-Isoser1)-PAR-1 (1-6) (huMan), (DL-Isoser1)-Proteinase Activated Receptor 1 (1-6) (huMan), (DL-Isoser1)-ThroMbin Receptor 1 (1-6) (huMan), (DL-Isoser1)-ThroMbin Receptor Activator Peptide 6, (DL-Isoser1)-Coagulation Factor II Receptor (1-6) (huMan)
- (DL-Isoser1)-TRAP-6 trifluoroacetate salt
- L-Asparagine, 2-hydroxy-β-alanyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl- (9CI)
- L-Asparagine,N2-[N2-[N-[N-[N-(2-hydroxy-β-alanyl)-L-phenylalanyl]-L-leucyl]-L-leucyl]-L-arginyl]-
- (DL-Isoser?)-TRAP-6 trifluoroacetate salt
- CAS:
- 150242-29-8
- MF:
- C34H56N10O9
- MW:
- 748.87
- Mol File:
- 150242-29-8.mol
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H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH Chemical Properties
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- pka
- 3.17±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- {DL-Isoser}-Phe-Leu-Leu-Arg-Asn
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H-DL-ISOSER-PHE-LEU-LEU-ARG-ASN-OH Usage And Synthesis
Uses
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. iso-TRAP-6 is an analog of TRAP-6 (HY-P0078) that refers to the use of isoserine instead of serine as first amino acid[1].
IC 50
PAR1
References
[1] Gremmel T, et, al. Sex-specific platelet activation through protease-activated receptor-1 in patients undergoing cardiac catheterization. Atherosclerosis. 2021 Dec;339:12-19. DOI:10.1016/j.atherosclerosis.2021.11.011
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