1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride Basic information
- Product Name:
- 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
- Synonyms:
-
- 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HYDROCHLORIDE
- SB-203186,SB 203186,SB203186,SB 203186 hydrochloride,carbachol,SB203186 hydrochloride,peristaltic,5-HT Receptor,Inhibitor,Serotonin Receptor,inhibit,5-hydroxytryptamine Receptor,tachycardia,reflex
- CAS:
- 207572-69-8
- MF:
- C16H21ClN2O2
- MW:
- 308.81
- Mol File:
- 207572-69-8.mol
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1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride Chemical Properties
- storage temp.
- 4°C, protect from light
- solubility
- Water:10.0(Max Conc. mg/mL);32.46(Max Conc. mM)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 100 mM in water
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1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride Usage And Synthesis
Uses
SB203186 is a potent 5HT4?serotonin receptor antagonist.
in vivo
Intraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg[1].
SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency[1].
1-Piperidinylethyl-1H-indole-3-carboxylate hydrochlorideSupplier
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