CALCIUM TITRIPLEX(R), DIHYDRATE
CALCIUM TITRIPLEX(R), DIHYDRATE Basic information
- Product Name:
- CALCIUM TITRIPLEX(R), DIHYDRATE
- Synonyms:
-
- Calciumtitriplexdihydrate
- PhEur,BP,USP
- Calcium disodium edta dihydrate
- ETHYLENDIAMINTETRAACETIC CALCIUM DISODIU
- Ca(Ⅱ)-EDTA disodium dihydrate
- CAS:
- 6766-87-6
- MF:
- C10H16CaN2Na2O10
- MW:
- 410.3
- Mol File:
- 6766-87-6.mol
CALCIUM TITRIPLEX(R), DIHYDRATE Chemical Properties
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
CALCIUM TITRIPLEX(R), DIHYDRATE Usage And Synthesis
Uses
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning[2][3].
in vivo
CaⅡ-EDTA disodium dehydrate (50 mg/kg, p.o. for 4 weeks) alleviates the toxic effects of cadmium on kidney and bone with preference to the nanoparticles form[2].
| Animal Model: | Sprague Dawley rats [2] |
| Dosage: | 50 mg/kg/day |
| Administration: | p.o. for 4 weeks (three-day break after each four consecutive days of administration) |
| Result: | Increased the body weight compared to the Cd-intoxicated group. Decreased in serum creatinine and cadmium concentration compared to the Cd-intoxicated group. Showed a good radio-density of the skeleton. |
References
[1] Miura, T. et al., Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria. Journal of Biomedical Science and Engineering, 5, 10-14.
[2] Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biol Trace Elem Res. 2023 Sep 18. DOI:10.1007/s12011-023-03842-6
[3] Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33. DOI:10.1002/jbt.20027
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