CADP-RIBOSE Chemical Properties

Boiling point:

934.8±75.0 °C(Predicted)

Density 

2.57±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)

form 

lyophilized powder

pka

0.97±0.70(Predicted)

color 

White to off-white

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

CADP-RIBOSE Usage And Synthesis

Uses

Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca²⁺ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.

Definition

ChEBI: A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.

Biochem/physiol Actions

Mobilizes intracellular Ca2+; regulates Ca2+-induced Ca2+?release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants.

CADP-RIBOSE(119340-53-3)Related Product Information

• NAD+
• DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*
• 3-DEAZA-CADP-RIBOSE
• 8-AMINO-CADP-RIBOSE
• BR-CADP-RIBOSE,8-BROMO-CADP-RIBOSE
• ANTI-CADP-RIBOSE
• NPE-CAGED CADP-RIBOSE
• CADP-RIBOSE
• 6-(BETA-HYDROXYETHYLAMINO)-PURINE