(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE Chemical Properties

Boiling point:

799.7±70.0 °C(Predicted)

Density 

1.414±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

63.01mg/ml in DMSO; 63.01mg/ml in ethanol

pka

14.14±0.40(Predicted)

form 

Solid

color 

White to off-white

(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE Usage And Synthesis

Uses

SSR 149415 is a vasopressin V1b receptor antagonist.

Biological Activity

SSR149415 is an orally active, selective vasopressin V1b receptor antagonist (human/r at Ki in nM = 1.5/1.3/V1b, 91/1050/V1a, 1412/2897/V2, 174/270/OT) th at inhibits 30 nM AVP-induced Ca2+ response in human and r at V1b CHO transfectants (Ki = 1.26/2.0 nM). SSR149415 suppresses AVP-mediated physiological responses in vivo, including corticotropin secretion (1-30 mg/kg p.o. or i.p. in rats) upon exogenous AVP administration (0.3 μg/kg alone or 0.03 μg/kg with 0.1 μg corticoliberin/kg via i.v.), restraint stress-Induced corticotropin secretion (EC50 = 10 mg/kg i.p. in rats), and in a murine model of anxiety (four-plate test; 1-10 mg/kg i.p. or 3-10 mg/kg p.o. acute or 10 mg/kg/day p.o.).

storage

Store at -20°C

(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE(439687-69-1)Related Product Information

• (S)-(-)-N-ISOPROPYL-1-PHENYLETHYLAMINE HYDROCHLORIDE
• (R)-N-(2-PROPYL)-1-PHENYLETHYLAMINE HYDROCHLORIDE
• (R)-(+)-1-Benzyl-3-pyrrolidinol
• (R)-1-(3-Chlorophenyl)ethanamine
• (S)-1-(2-Methoxyphenyl)ethylamine
• 2-(Diisopropylamino)ethanol hydrochloride
• (R)-1-(2-Methoxyphenyl)ethylamine
• (S)-1-(3-Chlorophenyl)ethylamine
• (2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE
• (1-ISOPROPYL-2-PYRROLIDINYL)METHYLAMINE
• 2-PHENYL-2-PYRROLIDINYLETHYLAMINE
• 2-(3-chlorophenyl)-2-pyrrolidin-1-ylethanamine
• H-PHG-NH2 HCL
• 1-(3-CHLOROPHENYL)-N1,N1-DIMETHYL-1,2-ETHANEDIAMINE
• 1-(alpha-Methylbenzyl)pyrrolidine hydrochloride
• (1-Isopropyl-2-pyrrolidinyl)-N-methylmethanamine
• 2-phenyl-2-pyrrolidin-1-ylacetamide
• 2-(Diethylamino)-2-phenylacetamide hydrochloride