Stanozolol Chemical Properties

Melting point:

242 °C

alpha 

34 º

Boiling point:

490.8±45.0 °C(Predicted)

Density 

1.129±0.06 g/cm3(Predicted)

refractive index 

34 ° (C=0.4, CHCl3)

Flash point:

-2℃

storage temp. 

2-8°C

solubility 

Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.

form 

powder

pka

15.15±0.60(Predicted)

color 

white to light yellow

Merck 

8794

InChIKey

LKAJKIOFIWVMDJ-IYRCEVNGSA-N

CAS DataBase Reference

10418-03-8

NIST Chemistry Reference

Stanozolol(10418-03-8)

Safety Information

Hazard Codes 

Xn,Xi,T,F

Risk Statements 

63-38-19-11-61-60

Safety Statements 

53-22-36/37/39-36-26-45

RIDADR 

UN2252 - class 3 - PG 2 - 1,2-Dimethoxyethane solution

WGK Germany 

3

RTECS 

BV8741000

HS Code 

29372900

Hazardous Substances Data

10418-03-8(Hazardous Substances Data)

MSDS

• Language:English Provider:Androstanazol
• Language:English Provider:SigmaAldrich

Stanozolol Usage And Synthesis

Description

Stanozolol (Item No. 21167) is an analytical reference standard that is categorized as a synthetic anabolic androgenic steroid. Stanozolol has low urinary excretion; therefore, its metabolites are usually used for detection. Formulations containing stanozolol are used as a treatment for hereditary angioedema. It has also been abused in athletics to improve performance. Stanozolol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.

Description

Stanozolol is a synthetic anabolic-androgenic steroids (AAS) belonging to the dihydrotestosterone group. It can be used for the treatment of wasting diseases, burn victims, osteroporosis, bone fractures, anemia and even obesity. It can stimulate fat loss without causing reduced lean body mass, inducing hemoglobin production and red blood cell formation. Stanozolol has the following physiological functions: (1) reduction of sex-hormone-binding-globulin; (2) inducing protein synthesis; (3) Maintain nitrogen retention; (4) Increase red blood cells; (5) inhibit glucocorticoids.

Chemical Properties

White Solid

Originator

Winstrol,Winthrop,US,1961

Uses

Anabolic steroid. Androgen. Controlled substance.

Uses

androgen anabolic steroid

Definition

ChEBI: An organic heteropentacyclic compound resulting from the formal condensation of the 3-keto-aldehyde moiety of oxymetholone with hydrazine. Like oxymetholone, it is a synthetic anabolic steroid. It has both anabolic and androgenic properties, and has been u ed to treat hereditary angioedema and various vascular disorders. It has also been widely abused by professional athletes.

Manufacturing Process

To a stirred solution of 1.00 gram of 17β-hydroxy-17α-methyl-4- androsteno[3,2-c]pyrazole in 200 ml of tetrahydrofuran and 400 ml of liquid ammonia was added 2.12 grams of lithium wire during 5 minutes. The dark blue mixture was stirred for 45 minutes. A solution of 40 ml of tertiary-butyl alcohol in 160 ml of diethyl ether was added with stirring.
After 15 minutes, 25 ml of ethanol was added with stirring. The mixture turned colorless after several hours, and the liquid ammonia was allowed to evaporate and the mixture was allowed to warm to room temperature over a period of about 15 hours.
The solvent was evaporated to yield a colorless solid residue, which was taken up in ethyl acetate-ice water. The two layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with water, saturated sodium chloride solution and filtered through anhydrous sodium sulfate. The solvent was evaporated to yield 1.20 grams of light tan crystals, MP 151° to 155°C, ultraviolet maximum at 224 mμ (E = 4,095). Two recrystallizations from ethanol afforded: 1st crop, 0.619 grams (62%) of colorless crystals (dried at 120°C in vacuo for 17 hours), MP 232.8° to 238.0°C, ultraviolet maximum at 224 mμ (E = 4,840); 2nd crop, 0.142 gram (14%) of colorless crystals, MP 234° to 242°C.

brand name

Winstrol (Ovation).

Therapeutic Function

Anabolic

Synthesis

Stanozol, 17|á-methyl-5|á-androstano[3,2-c]pyrazol-17|?-ol (29.3.13), is made by reducing the double bond at C4¨CC5 in methyltestosterone, which has independent interest as an anabolic drug of mestanolone (29.3.11). Mestanolone undergoes formylation with ethylformate in the presence of sodium ethoxide, forming a 2-formyl (oxymethylene) derivative (29.3.12), which upon reaction with hydrazine easily cyclizes to the desired stanazole (29.3.13), which is a pyrazol-condensed steroid system.

Veterinary Drugs and Treatments

Labeled indications for the previously marketed veterinary stanozolol product Winstrol?-V (Winthrop/Upjohn) included “…to improve appetite, promote weight gain, and increase strength and vitality…” in dogs, cats and horses. The manufacturer also stated that: “Anabolic therapy is intended primarily as an adjunct to other specific and supportive therapy, including nutritional therapy.”
Like nandrolone, stanozolol has been used to treat anemia of chronic disease. Because stanozolol has been demonstrated to enhance fibrinolysis after parenteral injection, it may be efficacious in the treatment of feline aortic thromboembolism or thrombosis in nephrotic syndrome; however, clinical studies and/or experience are apparently lacking for this indication at present.

References

https://www.steroid.com/Stanozolol.php
https://pubchem.ncbi.nlm.nih.gov/compound/stanozolol
https://en.wikipedia.org/wiki/Stanozolol

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