8-Chloro-3-Methoxy-[1,5]naphthyridine Chemical Properties

Boiling point:

312.2±37.0 °C(Predicted)

Density 

1.333±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.63±0.30(Predicted)

8-Chloro-3-Methoxy-[1,5]naphthyridine Usage And Synthesis

Uses

8-chloro-3-methoxy-1,5-naphthyridine can be used in the preparation of cyclopropane dicarboxamides for treating kinase-dependent disorders. It can be used in the preparation of N-substituted benzamides as Aurora kinase modulators useful in cancer-?related diseases. It is also useful in the preparation of C5-?C6-?carbocyclic fused iminothiadiazine dioxides as BACE inhibitors for treatment of Alzheimer''s disease and related disorders.