2-chloro-N-MethylpyriMidine-5-carboxaMide Chemical Properties

Boiling point:

455.4±18.0 °C(Predicted)

Density 

1.338±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

13.06±0.46(Predicted)

2-chloro-N-MethylpyriMidine-5-carboxaMide Usage And Synthesis

Synthesis

To a 100 mL round-bottomed flask were added methylamine hydrochloride (509 mg, 7.54 mmol, 1.20 eq.), methylene chloride (20 mL) and triethylamine (TEA, 1.92 g, 18.97 mmol, 3.00 eq.). 2-Chloropyrimidine-5-carbonyl chloride (1.11 g, 6.27 mmol, 1.00 eq.) was added slowly and dropwise at 0 °C in an ice bath. The reaction mixture was stirred at 20 °C for 2 hours. After completion of the reaction, the mixture was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:3, v/v). 760 mg (71% yield) of 2-chloro-N-methylpyrimidine-5-carboxamide was finally obtained as a light yellow solid.

References

[1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0497; 0500-0501

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