N-(4-Fluorobenzoyl)-5-aMino-1H-indole Chemical Properties

Boiling point:

374.9±22.0 °C(Predicted)

Density 

1.374±0.06 g/cm3(Predicted)

solubility 

DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml; DMSO: 16 mg/ml; Ethanol: 12.5 mg/ml

form 

A crystalline solid

pka

13.86±0.43(Predicted)

color 

Light brown to brown

N-(4-Fluorobenzoyl)-5-aMino-1H-indole Usage And Synthesis

Uses

N-(4-Fluorobenzoyl)-5-amino-1H-indole is a octamer-binding transcription factor 4 activating compound that activated Oct4 and Nanog promoters, which are essential regulators of embryonic stem cell (ESC) pluripotency and key to the reprogramming process.

Uses

Octamer-binding transcription factor 4 (Oct4) is a transcription factor which, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells. OAC3 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC3 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts.[Cayman Chemical]