2-AMINO-4-CYANO-PHENOL Chemical Properties

Melting point:

151-153℃

Boiling point:

345.1±32.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

7.63±0.18(Predicted)

color 

Brown

Sensitive 

Air Sensitive

Stability:

Air Sensitive, Light Sensitive

InChI

InChI=1S/C7H6N2O/c8-4-5-1-2-7(10)6(9)3-5/h1-3,10H,9H2

InChIKey

ZEWCASRNRWXXSO-UHFFFAOYSA-N

SMILES

C(#N)C1=CC=C(O)C(N)=C1

CAS DataBase Reference

14543-43-2

Safety Information

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

3439

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2926907090

2-AMINO-4-CYANO-PHENOL Usage And Synthesis

Uses

2-Amino-4-cyano-phenol is primarily used as an organic intermediate.

Synthesis

Steps for the synthesis of 3-amino-4-hydroxybenzonitrile: 4-hydroxy-3-nitrobenzonitrile (10 g, 61 mmol) was dissolved in methanol (200 mL) at room temperature and 5% Pd/activated carbon catalyst (0.5 g) was added. Hydrogen was continuously passed into the reaction system via a hydrogen balloon for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 3-amino-4-hydroxybenzonitrile (8.2 g, 100% yield).

References

[1] Patent: US6207697, 2001, B1
[2] Patent: US5886044, 1999, A
[3] Patent: US5780483, 1998, A
[4] Patent: US6262113, 2001, B1
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 12, p. 1545 - 1548

2-AMINO-4-CYANO-PHENOL(14543-43-2)Related Product Information

• Phenol
• 4-METHOXY-3-NITROBENZONITRILE
• Nitroxinil
• 4-Hydroxy-3-nitrobenzonitrile
• 3,4-Dihydro-2H-benzo[1,4]oxazine-6-carbonitrile
• 2-chloro-4-hydroxy-5-nitrobenzonitrile
• 3-amino-4-methoxybenzonitrile
• tert-butyl 5-cyano-2-hydroxyphenylcarbamate
• 5-amino-2-chloro-4-hydroxybenzonitrile
• 3-amino-4-(trifluoromethoxy)benzonitrile
• 2-AMINO-4-CYANO-PHENOL
• 3-nitro-4-(trifluoromethoxy)benzonitrile
• AKOS B029168
• 3,4-dihydroxy-5-nitro-benzonitrile
• AKOS B028760
• 2-METHYL-3-OXO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE-6-CARBONITRILE
• AKOS B028758
• 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-6-CARBONITRILE HYDROCHLORIDE