(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID Chemical Properties

Boiling point:

559.9±60.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

Soluble to 100 mM in 1.1eq. NaOH

form 

Powder

pka

1.34±0.40(Predicted)

(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID Usage And Synthesis

Uses

(RS)-APICA is a group II metabotropic glutamate receptor antagonist.

Biological Activity

The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.