Pracinostat Dihydrochloride Chemical Properties

InChI

InChI=1S/C20H30N4O2.ClH/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3;/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25);1H/b12-10+;

InChIKey

RCLMPSZFYQJPQD-VHPXAQPISA-N

SMILES

C(N1C(=NC2=CC(/C=C/C(=O)NO)=CC=C12)CCCC)CN(CC)CC.Cl

Pracinostat Dihydrochloride Usage And Synthesis

Description

Pracinostat Dihydrochloride is a potent histone deacetylase (HDAC) inhibitor with an IC50 of 40-140 nM, used in cancer research. It also inhibits the activity of metallo-β-lactamase structural domain-containing protein 2 (MBLAC2) hydrolase with an EC50 of less than 10 nM.