m-PEG4-(CH2)3-acid
m-PEG4-(CH2)3-acid Basic information
- Product Name:
- m-PEG4-(CH2)3-acid
- Synonyms:
-
- m-PEG4-(CH2)3-acid
- m-PEG4-CH2-acid
- tert-butyl 2,5,8,11-tetraoxapentadecan-15-oate
- 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]butanoic acid
- 5,8,11,14-Tetraoxapentadecanoic acid
- mPEG3-(CH2)3COOH
- CAS:
- 874208-84-1
- MF:
- C11H22O6
- MW:
- 250.29
- Mol File:
- 874208-84-1.mol
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m-PEG4-(CH2)3-acid Chemical Properties
- Boiling point:
- 366.2±32.0 °C(Predicted)
- Density
- 1.087±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- pka
- 4.63±0.10(Predicted)
- color
- Colorless to light yellow
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m-PEG4-(CH2)3-acid Usage And Synthesis
Description
m-PEG4-(CH2)3-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9. DOI:10.1021/mp2005774
m-PEG4-(CH2)3-acidSupplier
Nanjing Junnahe Biopharmaceutical Co., Ltd
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- 025-58367986 17351780683
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Shanghai EFE Biological Technology Co., Ltd.
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Jinan elephant international trading co., LTD
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Zhengzhou Acme Chemical Co., Ltd.
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Xi'an Confluore Biological Technology Co., Ltd.
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- 1924344760@qq.com