5-METHOXYPYRIDAZIN-3(2H)-ONE Chemical Properties

Melting point:

148-150 °C

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

10.57±0.40(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C5H6N2O2/c1-9-4-2-5(8)7-6-3-4/h2-3H,1H3,(H,7,8)

InChIKey

NRILSJUKEHQBLU-UHFFFAOYSA-N

SMILES

C1(=O)NN=CC(OC)=C1

5-METHOXYPYRIDAZIN-3(2H)-ONE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-methoxypyridazin-3(2H)-one from the compound (CAS: 938045-16-0): a mixture of 10% palladium/carbon (100 mg), 2-((benzyloxy)methyl)-4-chloro-5-methoxypyridazin-3(2H)-one (1.34 g), and acetic acid (10 mL) was subjected to a hydrogen atmosphere (0.8 MPa) with the addition of methanol (30 mL) and the reaction was stirred at 50 °C for 10 hours. After completion of the reaction, the insoluble material was removed by filtration and the solvent was removed by distillation under reduced pressure to afford the target product 5-methoxypyridazin-3(2H)-one (611 mg). Mass spectrometry analysis showed m/z (M + H): 127.

References

[1] Patent: US2015/322063, 2015, A1. Location in patent: Paragraph 2479; 2480; 2481

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