BMS-955829
BMS-955829 Basic information
- Product Name:
- BMS-955829
- Synonyms:
-
- BMS-955829
- (4R,5R)-5-(2,5-DIFLUOROPHENYL)-4-(5-(PHENYLETHYNYL)PYRIDIN-3-YL)OXAZOLIDIN-2-ONE
- 2-Oxazolidinone, 5-(2,5-difluorophenyl)-4-[5-(2-phenylethynyl)-3-pyridinyl]-, (4R,5R)-
- CAS:
- 1375751-08-8
- MF:
- C22H14F2N2O2
- MW:
- 376.36
- Mol File:
- 1375751-08-8.mol
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BMS-955829 Chemical Properties
- Boiling point:
- 589.2±50.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- pka
- 10.38±0.60(Predicted)
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BMS-955829 Usage And Synthesis
Description
BMS-955829 is a Positive allosteric modulators (PAMs). BMS-955829 shows high functional PAM potency, excellent mGluR5 binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. BMS-955829 is a potent mGluR5 PAM (EC50 = 2.6 ± 1.0 nM; n = 6), devoid of inherent mGluR5 agonist activity (EC50 > 30μM). The measured binding Ki of BMS-955829 was found to be 1.6 nM, which was in good agreement with its functional potency.