AFG206
AFG206 Basic information
- Product Name:
- AFG206
- Synonyms:
-
- AFG206
- Urea, N-(4-ethylphenyl)-N'-[4-(4-pyridinyloxy)phenyl]-
- CAS:
- 630122-37-1
- MF:
- C20H19N3O2
- MW:
- 333.38
- Mol File:
- 630122-37-1.mol
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AFG206 Usage And Synthesis
Description
AFG206 is the novel first-generation "type II" FLT3 inhibitor.
Uses
AFG206 is a first-generation ATP competitive “type II” FLT3 inhibitor. AFG206 potently inhibits cell proliferation (IC50 around 0.1 μM) via induction of Apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells. AFG206 is promising for research of acute myeloid leukemia[1].
References
[1] Weisberg E, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. DOI:10.1177/1947601910396505
AFG206Supplier
BOC Sciences
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- 1-631-485-4226; 16314854226
- info@bocsci.com
Suzhou Zhixin Biotechnology Co., Ltd.
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- 0512-65118909 18100677375
- sales@szzxbio.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
TargetMol Chemicals Inc.
- Tel
- +17819995354
- marketing@targetmol.com