BI-4834
BI-4834 Basic information
- Product Name:
- BI-4834
- Synonyms:
-
- BI-4834
- Benzamide, N-[trans-4-[(2R,6S)-2,6-dimethyl-4-morpholinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-
- CAS:
- 876371-13-0
- MF:
- C32H47N7O4
- MW:
- 593.76
- Mol File:
- 876371-13-0.mol
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BI-4834 Chemical Properties
- Density
- 1.24±0.1 g/cm3(Predicted)
- pka
- 14.24±0.40(Predicted)
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BI-4834 Usage And Synthesis
Description
BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536.