4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid
4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Basic information
- Product Name:
- 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid
- Synonyms:
-
- Prucalopride Impurity 35
- Prucalopride Impurity 9/methyl 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
- 7-Benzofurancarboxylic acid, 4-amino-5-chloro-2,3-dihydro-, methyl ester
- Prucalopride impurity D Methyl 4-amino-5chloro-2,3dihydrobenzofuran7-carboxylate
- CAS:
- 182808-04-4
- MF:
- C10H10ClNO3
- MW:
- 227.64
- Mol File:
- 182808-04-4.mol
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4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Chemical Properties
- Boiling point:
- 425.1±45.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.13±0.20(Predicted)
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4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Usage And Synthesis
Uses
Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. In addition, it is an intermediate in the preparation of enterokinetic agent R108512.
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