1,1,1-Trifluoroethyl-PEG5-Tos Chemical Properties

Boiling point:

495.8±45.0 °C(Predicted)

Density 

1.250±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Viscous Liquid

color 

Colorless to light yellow

1,1,1-Trifluoroethyl-PEG5-Tos Usage And Synthesis

Description

1,1,1-Trifluoroethyl-PEG5-Tos has a trifluoroethyl and tosyl attached to it. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

1,1,1-Trifluoroethyl-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005