Hydroxy-PEG3-methylamine Chemical Properties

storage temp. 

2-8°C, protect from light

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Liquid

color 

Light yellow to orange

Hydroxy-PEG3-methylamine Usage And Synthesis

Description

Hydroxy-PEG3-methylamine is a PEG linker containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc.

Uses

Hydroxy-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005