8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Chemical Properties

Melting point:

215-220℃

Density 

1.71±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.10±0.30(Predicted)

form 

Solid

color 

Brown

InChIKey

VKZJRJVVFDDJKP-UHFFFAOYSA-N

CAS DataBase Reference

68774-77-6

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2933998090

8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE Usage And Synthesis

Synthesis

Using 2-chloro-3-hydrazinopyrazine (8 g) and triethyl orthoformate (32 mL), the mixture was heated to reflux and stirred for 4 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, the precipitated solid was collected by filtration and washed with ethanol. The resulting solid was 8-chloro-[1,2,4]triazolo[4,3-A]pyrazine, which was dried under reduced pressure to give the product (8.10 g, 95% yield).

References

[1] Patent: JP5851663, 2016, B1. Location in patent: Paragraph 0301
[2] Patent: WO2009/64418, 2009, A1. Location in patent: Page/Page column 85
[3] Patent: US2010/120774, 2010, A1. Location in patent: Page/Page column 37-38

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