5-fluoro-1H-pyrimidine-2,4-dione Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: slightly soluble; Methanol: slightly soluble

form 

A solid

5-fluoro-1H-pyrimidine-2,4-dione Usage And Synthesis

Description

5-Fluorouracil-¹³C,¹⁵N₂ is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

Uses

Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.