(R)-3,4-DCPG Chemical Properties

Boiling point:

531.0±50.0 °C(Predicted)

Density 

1.634±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at RT

form 

Powder

pka

1.59±0.10(Predicted)

Water Solubility 

Soluble to 100 mM in water

(R)-3,4-DCPG Usage And Synthesis

Uses

(R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations[1].

Biological Activity

AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors.

References

[1] N K Thomas, et al. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur J Pharmacol. 1997 Nov 5;338(2):111-6. DOI:10.1016/s0014-2999(97)81937-1