5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemical Properties

Boiling point:

421.6±40.0 °C(Predicted)

Density 

1.192±0.06 g/cm3(Predicted)

storage temp. 

+2C to +8C

solubility 

DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml

form 

Tan solid

pka

5.00±0.10(Predicted)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Usage And Synthesis

Description

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC₅₀ = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

Uses

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.