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PARGYLINE HYDROCHLORIDE

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PARGYLINE HYDROCHLORIDE Basic information

Product Name:
PARGYLINE HYDROCHLORIDE
Synonyms:
  • N-METHYL-N-PROPARGYLBENZYLAMINE HYDROCHLORIDE
  • N-METHYL-N-(2-PROPYNY)BENZYLAMINE HYDROCHLORIDE
  • N-METHYL-N-2-PROPYNYLBENZYLAMINE HYDROCHLORIDE
  • PARGYLINE HYDROCHLORIDE
  • benzylmethylpropynylaminehydrochloride
  • n-benzyl-n-methyl-2-propynylaminehydrochloride
  • n-benzyl-n-methyl-2-propynylaminhydrochloride
  • n-methyl-n-2-propynyl-benzylaminhydrochloride
CAS:
306-07-0
MF:
C11H14ClN
MW:
195.69
EINECS:
206-175-1
Mol File:
306-07-0.mol
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PARGYLINE HYDROCHLORIDE Chemical Properties

Melting point:
160-163 °C(lit.)
storage temp. 
-20°C
solubility 
≥33.55 mg/mL in EtOH; ≥51.6 mg/mL in H2O; ≥7.55 mg/mL in DMSO
form 
A crystalline solid
color 
Crystals from EtOH/Et2O
Merck 
13,7110
BRN 
3699487
InChIKey
BCXCABRDBBWWGY-UHFFFAOYSA-N
CAS DataBase Reference
306-07-0
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
DP6650000
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2921199990
Toxicity
LD50 orl-rat: 250 mg/kg 27ZQAG -,401,72

MSDS

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PARGYLINE HYDROCHLORIDE Usage And Synthesis

Originator

Eutonyl, Abbott , US ,1963

Uses

Pargyline hydrochloride has been used:

  • as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
  • to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
  • to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Uses

Antihypertensor;Monoamine oxidase inhibitor

Manufacturing Process

A mixture of 23.8 grams (0.2 mol) of propargyl bromide, 24.2 grams (0.2 mol) of N-methylbenzylamine and 400 ml of anhydrous ethanol in the presence of 42.4 grams (0.4 mol) of anhydrous sodium carbonate was heated at the boiling temperature and under reflux for a period of 17 hours.
The sodium carbonate was then removed by filtration and the alcohol was removed by distillation under reduced pressure. The residue was treated with 300 ml of dry ether and the resulting solution was filtered to remove sodium bromide.
The filtrate was dried and fractionally distilled under reduced pressure to obtain the desired N-methyl-N-propargylbenzylamine which boiled at 96°97°C at 11 mm pressure.
Analysis calculated for C11H13N: C = 82.97%; H = 8.23%; N = 8.80%. Found: C = 82.71%; H = 8.51%; N = 8.93%.
The hydrochloride salt of this amine was prepared by dissolving the amine in ether and adding ethereal hydrogen chloride to the ether solution. The solid hydrochloride salt which precipitated was recrystallized from an ethanol-ether mixture and was found to melt at 154° - 155°C.

brand name

Eutonyl (Abbott).

Therapeutic Function

Antihypertensive

Biological Activity

pargyline, an irreversible and non-selective inhibitor of mao, is used to treat moderate hypertension and cancer cells. there are two isoforms of mao, mao-a and mao-b. mao-a preferentially deaminates melatonin, serotonin, norepinephrine and epinephrine. mao-b catalyzes the oxidative deamination and inactivation of certain catecholamines within the presynaptic nerve terminals.

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.

Safety Profile

Poison by ingestion,intraperitoneal, and intravenous routes. Human systemiceffects by ingestion: effects on fluid intake, psychologicaleffects. Experimental reproductive effects. When heatedto decomposition it emits very toxic fumes of HCl andNOx.

in vitro

pargyline reduced the proliferation of human prostate carcinoma (lncap-ln3) cells in a time- and dose-dependent fashion. in addition, compared to the control, pargyline remarkably triggered cell cycle arrest at the g1 phase. pargyline elicited an increase in the cell death rate via promoting apoptosis, suggesting that pargyline was a powerful candidate drug for the treatment of human prostate cancer [1].

in vivo

male rats were injected intraperitoneally pargyline at a dose of 75 mg/kg for 80 min. pargyline significantly increased the concentration of extracellular dopamine in the striatum and simultaneously, significantly reduced the concentration of extracellular mao-derived metabolite 3,4-dihydroxyphenylacetic acid to undetectable levels [2].

IC 50

11.52 nm: inhibits monoamine oxidase (mao) type a (mao-a).

References

[1]. chai, y. effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. oncology reports. 2013.
[2]. desvignes, c., bert, l., vinet, l., denoroy, l., renaud, b., & lambás-seas, l. evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid. neuroscience letters. 1999; 261(3):175-178.

PARGYLINE HYDROCHLORIDESupplier

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