5-Bromo-2-hydrazinopyridine Chemical Properties

Melting point:

132.0 to 136.0 °C

Boiling point:

238.2±50.0 °C(Predicted)

Density 

1.82±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

form 

powder to crystal

pka

8.97±0.70(Predicted)

color 

White to Light yellow to Light orange

CAS DataBase Reference

77992-44-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-37/38-41

Safety Statements 

26-36-45

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2933399990

5-Bromo-2-hydrazinopyridine Usage And Synthesis

Synthesis

2-Chloro-5-bromopyridine (64 g, 333 mmol) was suspended in hydrazine monohydrate (250 mL), and the mixture was heated at 70° C. for 72 hours. The reaction mixture was then diluted with water (750 mL), and the resulting precipitate was filtered off and azeotrope, firstly with toluene (*2) and then dichloromethane (*2), to afford 5-Bromo-2-hydrazinopyridine as a pale brown solid in 83percent yield, 52 g.

References

[1] Patent: US2006/35922, 2006, A1. Location in patent: Page/Page column 31
[2] Patent: WO2007/91152, 2007, A1. Location in patent: Page/Page column 48
[3] Patent: WO2012/65546, 2012, A1. Location in patent: Page/Page column 19
[4] Patent: WO2012/65297, 2012, A1. Location in patent: Page/Page column 19
[5] Patent: US2010/305085, 2010, A1. Location in patent: Page/Page column 17

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