BENZOFURAN-3-CARBALDEHYDE Chemical Properties

Melting point:

39℃ (ligroine )

Boiling point:

165℃ (18 Torr)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Solid

color 

White to yellow

Safety Information

HS Code 

2932990090

BENZOFURAN-3-CARBALDEHYDE Usage And Synthesis

Uses

Benzofuran-3-carbaldehyde is a bioactive chemical, and can be used for the synthesis of active compound[1].

Synthesis

The general procedure for the synthesis of 3-formylbenzofuran from 3-methylbenzofuran was as follows: 3-methylbenzofuran (200 mg, 0.19 mL, 1.5 mmol) and selenium dioxide (SeO2, 200 mg, 1.8 mmol, 1.2 eq.) were suspended in 1,4-dioxane (3 mL) and heated and refluxed for 24 hours. Upon completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with ethyl acetate/hexane (2:1 v/v, 10 mL), and filtered through a short silica gel plug to remove the selenium residue. The silica gel plugs were washed with ethyl acetate (2 x 3 mL), and the organic filtrates were combined and evaporated to dryness. Purification by silica gel column chromatography (eluent: hexane/ethyl acetate 96:4) afforded the yellow oily product 3-formylbenzofuran (162 mg, 1.1 mmol, 74% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 10.18 (s, 1H), 8.26 (s, 1H), 8.19 (m, 1H), 7.54 (m, 1H), 7.41 (m, 2H); ESI-MS m/z = 147.0 ([MH]+), calculated value C9H7O2 = 147.04.

References

[1] Bolling BW, et al. Phenolic derivatives from soy flour ethanol extract are potent in vitro quinone reductase (QR) inducing agents. J Agric Food Chem. 2008 Nov 26;56(22):10473-80. DOI:10.1021/jf801541t

BENZOFURAN-3-CARBALDEHYDE(4687-25-6)Related Product Information

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• N3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-4,5,6,7-TETRAFLUORO-2-METHYLBENZO[B]FURAN-3-CARBOXAMIDE
• CHEMBRDG-BB 5169029