6-BROMO-2-QUINAZOLINAMINE Chemical Properties

Boiling point:

425.3±37.0 °C(Predicted)

Density 

1.744±0.06 g/cm3(Predicted)

storage temp. 

Room temperature.

pka

4.94±0.26(Predicted)

Appearance

Light yellow to brown Solid

InChI

InChI=1S/C8H6BrN3/c9-6-1-2-7-5(3-6)4-11-8(10)12-7/h1-4H,(H2,10,11,12)

InChIKey

IJXKEDDKGGBSBX-UHFFFAOYSA-N

SMILES

N1=C2C(C=C(Br)C=C2)=CN=C1N

Safety Information

HS Code 

2933998090

6-BROMO-2-QUINAZOLINAMINE Usage And Synthesis

Synthesis

5-Bromo-2-fluorobenzaldehyde (10 g, 49.2 mmol) and guanidine carbonate (13.3 g, 74 mmol) were dissolved in N,N-dimethylacetamide (50 mL). The reaction mixture was heated to reflux temperature with continuous stirring for 5 hours. Upon completion of the reaction, it was cooled to room temperature, water (120 mL) was added and stirring was continued for 2 hours at room temperature. The resulting 6-bromo-2-quinazolinamine was collected by filtration and subsequently dried under vacuum to give the final product (5.0 g, 60% yield).

References

[1] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 49
[2] European Journal of Medicinal Chemistry, 2017, vol. 141, p. 506 - 518
[3] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3959 - 3962
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 19, p. 5671 - 5686
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 11, p. 3065 - 3068

6-BROMO-2-QUINAZOLINAMINE(190273-89-3)Related Product Information

• METHYL 6-BROMOQUINOLINE-2-CARBOXYLATE
• 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE
• 6-BROMO-2-PHENYL-1H-IMIDAZO[4,5-B]PYRIDINE
• Methyl-6-bromopyrazine-2-carboxylate
• 4-Amino-6-bromo-2-methylpyrimidine
• 6-BROMO-2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID
• 6-Bromoquinoline-2-carboxylic acid
• 6-BroMo-2-fluoro-pyridin-3-aMine
• 6-Bromo-2-fluoro-3-hydroxypyridine
• Tiotropium bromide
• 6-BROMO-2-QUINAZOLINAMINE
• 6-Bromoquinolin-2-amine
• 6-BROMO-N,N-DIMETHYL-2-QUINAZOLINAMINE
• 6-Bromo-quinazoline-2,4-diamine
• 4-[(6-BROMO-4-PHENYLQUINAZOLIN-2-YL)AMINO]BENZOIC ACID
• 1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride
• 3-[(6-BROMO-4-PHENYLQUINAZOLIN-2-YL)AMINO]BENZOIC ACID
• 1-(4-Amino-6,8-dibromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride