MMP INHIBITOR I
MMP INHIBITOR I Basic information
- Product Name:
- MMP INHIBITOR I
- Synonyms:
-
- P-aminobenzoyl-gly-pro-D-leu-D-ala*hydroxamic aci
- 4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH
- METALLOPROTEASE INHIBITOR 1
- MATRIX METALLOPROTEINASE INHIBITOR I
- 4-aminobenzoyl-gly-pro-d-leu-d-ala hydroxamic acid
- D-AlaninaMide, N-(4-aMinobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-
- 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt
- H-4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH
- CAS:
- 124168-73-6
- MF:
- C23H34N6O6
- MW:
- 490.55
- Product Categories:
-
- Inhibitor of human matrix metalloproteinases.
- Mol File:
- 124168-73-6.mol
MMP INHIBITOR I Chemical Properties
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: 1 mg/mL
- pka
- 9.34±0.40(Predicted)
- form
- solid
- color
- white
- Water Solubility
- water: 1mg/mL
MSDS
- Language:English Provider:SigmaAldrich
MMP INHIBITOR I Usage And Synthesis
Uses
FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].
Biological Activity
Collagenase Inhibitor
in vivo
FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2].
References
[1] U Benbow, et al. Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis. 1999 May;17(3):231-8. DOI:10.1023/a:1006639214618
[2] H Anan, et al. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22(12):668-73. DOI:10.1016/S0099-2399(96)80061-6
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