CY 208-243
CY 208-243 Basic information
- Product Name:
- CY 208-243
- Synonyms:
-
- (-)-(6AR,12BR)-4,6,6A,7,8,12B-HEXAHYDRO-7-METHYLINDOLO[4,3-A]PHENANTHRIDIN
- (6aR)-4,6,6aα,7,8,12bβ-Hexahydro-7-methylindolo[4,3-ab]phenanthridine
- (6aR,12bβ)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-ab]phenanthridine
- (6aα,12bβ)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-ab]phenanthridine
- [6aR,12bR,(-)]-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-ab]phenanthridine
- (-)-(6aR,12bR)-4,6,6a,7,8,12β-Hexahydro-7-methylindolo[4,3-a]phenanthridin
- CY 208-243
- Indolo[4,3-ab]phenanthridine, 4,6,6a,7,8,12b-hexahydro-7-methyl-, (6aR,12bR)-
- CAS:
- 100999-26-6
- MF:
- C19H18N2
- MW:
- 274.36
- Product Categories:
-
- Dopamine receptor
- Mol File:
- 100999-26-6.mol
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CY 208-243 Chemical Properties
- Boiling point:
- 466.5±33.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO
- form
- Powder
- pka
- 17.40±0.20(Predicted)
- color
- White to off-white
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CY 208-243 Usage And Synthesis
Uses
CY 208-243 is a selective D1DR receptor agonist.
Definition
ChEBI: LSM-3788 is a member of phenanthridines.
Biological Activity
Centrally active dopamine D 1 receptor agonist, selective over D 2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC 50 of 125 nM. Unlike SKF 38393 ((?-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide ), it exerts anti-Parkinsonian activity in animal models.
in vivo
Pretreatment with CY 208-243 (2.5 mg/kg; s.c.) prevents the increase of DA release and metabolism induced by the D-1 antagonist, SCH 23390 (0.05 mg/kg; s.c.)[1].
| Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] |
| Dosage: | 2.5 mg/kg |
| Administration: | Subcutaneous |
| Result: | Prevented the increase of DA release and metabolism induced by the D-1 antagonist. |
IC 50
D1 Receptor
storage
Store at RT
CY 208-243Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
EMMX Biotechnology LLC
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- 888-539-0666
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Alfa Chemistry
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- +1-5166625404;
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
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BOC Sciences
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- info@bocsci.com