2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride
2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Basic information
- Product Name:
- 2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride
- Synonyms:
-
- 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine HCl
- 2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride
- 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride
- 2-(2-((6-Chlorohexyl)oxy)ethoxy)ethan-1-amine hydrochloride
- 2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylammonium hydrochloride
- Cl-C6-PEG2-NH2 hydrochloride
- Cl-C6-PEG2-NH2 (HCl salt)
- 2-[2-(6-chlorohexoxy)ethoxy]ethanamine
- CAS:
- 1035373-85-3
- MF:
- C10H23Cl2NO2
- MW:
- 260.2
- Mol File:
- 1035373-85-3.mol
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2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Chemical Properties
- form
- Solid
- color
- White to yellow
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2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Usage And Synthesis
Biological Activity
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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