2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Chemical Properties

storage temp. 

-20°C, sealed storage, away from moisture

form 

Solid

color 

White to yellow

InChI

InChI=1S/C10H22ClNO2.ClH/c11-5-3-1-2-4-7-13-9-10-14-8-6-12;/h1-10,12H2;1H

InChIKey

KRGPBUVQAULFOQ-UHFFFAOYSA-N

SMILES

C(CCCCCCl)OCCOCCN.Cl

2-[2-(6-chloro-hexyloxy)-ethoxy]-ethylamine hydrochloride Usage And Synthesis

Uses

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Biological Activity

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.