BMS-1001
BMS-1001 Basic information
- Product Name:
- BMS-1001
- Synonyms:
-
- BMS-1001
- D-Serine, N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]-
- 2113650-03-4 (free base)
- BMS 1001,BMS1001
- CAS:
- 2113650-03-4
- MF:
- C35H34N2O7
- MW:
- 594.65
- Mol File:
- 2113650-03-4.mol
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BMS-1001 Chemical Properties
- Boiling point:
- 801.2±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 50 mg/mL (84.08 mM);Ethanol: Insoluble
- pka
- 2.08±0.10(Predicted)
- Water Solubility
- Water: Insoluble
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BMS-1001 Usage And Synthesis
Uses
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction (IC50: 2.25 nM in a homogeneous time-resolved fluorescence binding assay).
Biological Activity
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. It attenuates the inhibitory effect of soluble PD-L1 on T cell receptor-mediated T lymphocyte activation.
target
| Target | Value |
| PD-1/PD-L1 (Cell-free assay) | 253 nM(EC50) |
BMS-1001Supplier
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. Gold
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- 17771424646
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Shanghai SuperLan Chemcial Technique Centre Gold
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- 021-2022843681 15618226720
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Shanghai Rechem science Co., Ltd.
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- 21-31433387 15618786686
- sales@rechemscience.com