CLOTIAZEPAM
CLOTIAZEPAM Basic information
- Product Name:
- CLOTIAZEPAM
- Synonyms:
-
- CLOTIAZEPAM
- 2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-
- 2H-Thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
- 2h-thieno(2,3-e)(1,4)diazepin-2-one,1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-m
- 2h-thieno(2,3e)(1,4)-diazepin-2-one,5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1
- 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
- 2H-Thieno[2,3-E]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
- 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno(2,3-e)(1,4)diazepi
- CAS:
- 33671-46-4
- MF:
- C16H15ClN2OS
- MW:
- 318.82
- EINECS:
- 251-627-3
- Product Categories:
-
- Agonist
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Mol File:
- 33671-46-4.mol
CLOTIAZEPAM Chemical Properties
- Melting point:
- 105-106°
- Boiling point:
- 523.7±50.0 °C(Predicted)
- Density
- 1.1625 (rough estimate)
- refractive index
- 1.6100 (estimate)
- solubility
- DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- form
- A crystalline solid
- pka
- 2.36±0.20(Predicted)
CLOTIAZEPAM Usage And Synthesis
Chemical Properties
Off-White Solid
Originator
Rize,Yoshitomi,Japan,1979
Uses
A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to be nzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.
Definition
ChEBI: Clotiazepam is an organic molecular entity.
Manufacturing Process
To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a flask provided with a water-removing adaptor. The reaction mixture is concentrated, and the residue is extracted with chloroform. The chloroform layer is washed with water and then with a sodium hydrogen carbonate solution, then dried over magnesium sulfate. The chloroform is distilled off under reduced pressure, and toluene is added to the residue. Thus is precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro- 3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C.
Therapeutic Function
Tranquilizer