rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Basic information
- Product Name:
- rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
- Synonyms:
-
- rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
- L-Leucine, N-[(2S,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-
- (2S)-2-[(2S,3R)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
- CAS:
- 87304-15-2
- MF:
- C21H32N2O6
- MW:
- 408.49
- Mol File:
- 87304-15-2.mol
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rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Usage And Synthesis
Description
E3 Ligase ligand 9 targets ubiquitin-protein ligases in order to activate the E3 ubiquitin ligase. It can then treat metabolic disorders and psychiatric disorders.
Uses
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
References
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168
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