2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Basic information
- Product Name:
- 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
- Synonyms:
-
- 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide
- CPD3616
- JBJ-04-125-02
- (Rac)-JBJ-04-125-02
- 2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-6-[4-(1-piperazinyl)phenyl]-N-2-thiazolyl-
- Allosteric,anti-proliferation,HER1,inhibit,ErbB-1,(Rac)JBJ0412502,Inhibitor,racemate,Epidermal growth factor receptor,anti-tumor,(Rac) JBJ 04 125 02,EGFR,T790M-mutant
- Compounds jbj-04-125-02
- CPD3616 CPD-3616
- CAS:
- 2140807-05-0
- MF:
- C29H26FN5O3S
- MW:
- 543.61
- Mol File:
- 2140807-05-0.mol
More
Less
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Chemical Properties
- form
- Solid
- color
- White to off-white
More
Less
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamide Usage And Synthesis
Uses
(Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor[1].
IC 50
EGFR (L858R/T790M): 0.26 nM (IC50)
References
[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903
2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2-yl)acetamideSupplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Hangzhou J&H Chemical Co., Ltd.
- Tel
- 0571-87396432
- sales@jhechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266