PAPP Chemical Properties

Melting point:

83-85 °C

Boiling point:

464.1±45.0 °C(Predicted)

Density 

1.218±0.06 g/cm3(Predicted)

solubility 

0.1 M HCl: slightly soluble

form 

solid

pka

7.85±0.10(Predicted)

color 

off-white

Safety Information

WGK Germany 

3

PAPP Usage And Synthesis

Uses

LY-165,163 is a selective 5-HT1A and 5-HT1D serotonin receptor antagonist.

Definition

ChEBI: LY-165163 is a N-arylpiperazine that is piperazine susbtituted by 2-(4-aminophenyl)ethyl and 3-(trifluoromethyl)phenyl groups at positions 1 and 4, respectively. It is a selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist. It has a role as a geroprotector and a serotonergic agonist. It is a N-arylpiperazine, a N-alkylpiperazine, a member of (trifluoromethyl)benzenes, a substituted aniline and a primary arylamine. It is functionally related to a 1-(3-(trifluoromethyl)phenyl)piperazine.