CLORGYLINE
CLORGYLINE Basic information
- Product Name:
- CLORGYLINE
- Synonyms:
-
- clorgiline
- m&b9302
- mandb9302
- n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-amin
- n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylamin
- N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine
- N-Methyl-N-[3-(2,4-dichlorophenoxy)propyl]-2-propyne-1-amine
- 2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-
- CAS:
- 17780-72-2
- MF:
- C13H15Cl2NO
- MW:
- 272.17
- Mol File:
- 17780-72-2.mol
CLORGYLINE Chemical Properties
- Boiling point:
- 361.3±37.0 °C(Predicted)
- Density
- 1.196±0.06 g/cm3(Predicted)
- pka
- 6.98±0.50(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
CLORGYLINE Usage And Synthesis
Uses
Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1].
Definition
ChEBI: An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
References
[1] Knoll J. The possible mechanisms of action of (-) deprenyl in Parkinson's disease[J]. Journal of Neural Transmission, 1978, 43: 177-198. DOI:10.1007/BF01246955
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