(S)-BAY 73-6691 Chemical Properties

Boiling point:

459.2±55.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

-1+-.0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

(S)-BAY 73-6691 Usage And Synthesis

Uses

(S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor[1].

References

[1] Li J, et al. Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease. Brain Res. 2016 Jul 1;1642:327-335. DOI:10.1016/j.brainres.2016.04.011