BTdCPU
BTdCPU Basic information
- Product Name:
- BTdCPU
- Synonyms:
-
- BTdCPU
- eIF2–GTP–tRNAiMetTernaryCompInhib, BTdCPU
- Urea, N-1,2,3-benzothiadiazol-6-yl-N'-(3,4-dichlorophenyl)-
- 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
- Inhibitor,BTdCPU,Phosphatase,inhibit,Apoptosis
- BTdCPU, 10 mM in DMSO
- CAS:
- 1257423-87-2
- MF:
- C13H8Cl2N4OS
- MW:
- 339.2
- Product Categories:
-
- API
- Mol File:
- 1257423-87-2.mol
BTdCPU Chemical Properties
- Density
- 1.664±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥ 250 mg/mL (737.03 mM)
- pka
- 11.75±0.43(Predicted)
- form
- Solid
- color
- White to off-white
BTdCPU Usage And Synthesis
Uses
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone.html" class="link-product" target="_blank">Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
in vivo
BTdCPU (175 mg/kg; i.p.; single daily for 21 days) inhibits tumor growth without toxicity in mice xenograft breast tumors model[2].
| Animal Model: | Female nude mice (mice xenograft breast tumors model)[2]. |
| Dosage: | 175 mg/kg |
| Administration: | Intraperitoneal injection; single daily for 21 days |
| Result: | Led to complete tumor stasis,which persisted for the remainder of the 3-week study Showed good safety in mice. |
References
[1] Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. DOI:10.1016/j.leukres.2017.01.007
[2] Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. DOI:10.1038/nchembio.613
BTdCPUSupplier
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