1-PHENYL-2-BUTANAMINE HYDROCHLORIDE Chemical Properties

Melting point:

143-144°C

solubility 

DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml

form 

A crystalline solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

1-PHENYL-2-BUTANAMINE HYDROCHLORIDE Usage And Synthesis

Description

Amphetamines are chemical compounds characterized by an α-methylphenethylamine base structure. D-amphetamine is a stimulant that binds the norepinephrine and dopamine transporters (EC₅₀s = 7.1 and 24.8 nM, respectively). 2-Amino-1-phenylbutane is an amphetamine characterized by having an ethyl group in the alpha position. It has emerged as a potential recreational drug. This product is a mixture of the D and L isomers. The D isomer of this compound partially substitutes for D-amphetamine in an animal discrimination analysis, suggesting that it weakly mimicks the signaling and stimulant properties of D-amphetamine. This product is intended for forensic and research applications.

Uses

1-Phenyl-2-butanamine Hydrochloride is a derivative of Amphetamine (A634248); a CNS stimulant and anorexic.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 31, p. 824, 1988 DOI: 10.1021/jm00399a024

References

[1] JAESIN LEE. Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: a research chemical or a new designer drug?[J]. Forensic Toxicology, 2012, 31 1: 54-58. DOI: 10.1007/s11419-012-0158-1
[2] PIETER A. COHEN  Bastiaan J V  John C Travis. A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement[J]. Drug Testing and Analysis, 2013, 6 7-8: 805-807. DOI: 10.1002/dta.1578
[3] ROBERT OBERLENDER  David E N. Structural variation and (+)-amphetamine-like discriminative stimulus properties[J]. Pharmacology Biochemistry and Behavior, 1991, 38 3: Pages 581-586. DOI: 10.1016/0091-3057(91)90017-v