2,2-DIMETHYLETHENYLBORONIC ACID Chemical Properties

Melting point:

87 °C

Boiling point:

190.6±23.0 °C(Predicted)

Density 

0.952±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

solid

pka

9.82±0.43(Predicted)

color 

White to off-white

Safety Information

HS Code 

2931900090

2,2-DIMETHYLETHENYLBORONIC ACID Usage And Synthesis

Uses

2,2-Dimethylethenylboronic acid is a useful reagent in the preparation of prostaglandins via 1,4-conjugate addition.

Synthesis

(1) the use of dichloromethane, at 10 ~ 60 conditions, the use of 3,3-dimethyl acrylic acid, and bromine reaction 3 ~ 4h, after the end of the reaction using a base to adjust the PH to 9 ~ 10,30 ~ 60 conditions of the reaction for 2 ~ 3h, the reaction is static after the end of the stratification, the organic layer distillation to obtain 2,2-dimethyl vinyl bromide;

(2) using tetrahydrofuran, at a temperature of -76 ~ -40 C, using 2,2-dimethyl vinyl bromide, in the lithium metal and boronization reagent under the action of the reaction 2 ~ 3h, using hydrochloric acid to adjust the PH to 3 ~ 4, using ethyl acetate extraction, concentrated organic layer by non-polar hydrocarbon solvent slurrying and filtration, drying to obtain 2,2-dimethyl vinylboronic acid.

2,2-DIMETHYLETHENYLBORONIC ACID(14559-88-7)Related Product Information

• Poly(diallyldimethylammonium chloride)
• 3-METHYL-2-BUTEN-2-YLBORONIC &
• cis-1-Propene-1-boronic acid
• 2,2-DIMETHYLETHENYLBORONIC ACID
• TRANS-1-PROPEN-1-YLBORONIC ACID
• 2,2-Dimethylethenylboronic acid pinacol ester