12(S)-HHT Chemical Properties

Boiling point:

451.8±45.0 °C(Predicted)

Density 

0.992±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

form 

ethanol solution

pka

4.75±0.10(Predicted)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1170 3/PG 2

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

12(S)-HHT Usage And Synthesis

Uses

12(S)-HHTrE is an unusual product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of the human platelet. It is biosynthesized by thromboxane synthase (TX synthase) from prostaglandin H2 (PGH2) concurrently with TXA2. The biological role of 12(S)-HHTrE is uncertain. It is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.

Uses

12(S)-HHTrE is a metabolite of arachidonic acid (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

Definition

ChEBI: A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent.

12(S)-HHT(54397-84-1)Related Product Information

• 2,4-HEPTADIEN-1-OL
• 1,3,6-HEPTATRIENE
• 12(S)-HHT