COBINAMIDE DICYANIDE Chemical Properties

storage temp. 

-20°C

form 

powder

color 

purple to very dark purple

biological source

synthetic (organic)

Merck 

13,3900

Safety Information

Hazard Codes 

Xn

Risk Statements 

68-22

Safety Statements 

36-37

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

COBINAMIDE DICYANIDE Usage And Synthesis

Uses

Dicyanocobinamide has been used for the crystallization of vitamin B12-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.', 'For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations.

Biological Activity

Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase.

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