ICI 89406
ICI 89406 Basic information
- Product Name:
- ICI 89406
- Synonyms:
-
- N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA
- ICI 89406
- C025716
- Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-
- 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea
- Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
- ICI 89406, 10 mM in DMSO
- CAS:
- 53671-71-9
- MF:
- C19H22N4O3
- MW:
- 354.4
- Mol File:
- 53671-71-9.mol
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ICI 89406 Chemical Properties
- Melting point:
- 155-156 °C(Solv: acetonitrile (75-05-8))
- Boiling point:
- 575.0±50.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in ethanol and to 100 mM in DMSO
- form
- Powder
- pka
- 12.29±0.46(Predicted)
- color
- White to off-white
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ICI 89406 Usage And Synthesis
Uses
ICI 89406 is beta-1-selective antagonist.
Definition
ChEBI: 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea is a member of ureas.
Biological Activity
β -adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.
in vivo
| Animal Model: | Rats[2]. |
| Dosage: | 0.6, 5 or 50 mg/kg. |
| Administration: | Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis). |
| Result: | Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%. |
ICI 89406Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
SPIRO PHARMA
- Tel
- eric_feng1954@126.com
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com