PPADS TETRASODIUM SALT
PPADS TETRASODIUM SALT Basic information
- Product Name:
- PPADS TETRASODIUM SALT
- Synonyms:
-
- PPADS Tetrasodium
- PPADS tetrasodium salt, anhydrous
- PPADS (sodium salt)
- 4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonate
- PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT
- PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA
- PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
- PPADS
- CAS:
- 192575-19-2
- MF:
- C14H15N3NaO12PS2
- MW:
- 535.37
- Product Categories:
-
- Adenosines/P2 Nucleotide Receptor - Antagonists
- Adenosines/P2 Nucleotide Receptors (Purinergics)
- GPCR Modulators
- GPCR Proteins
- Ligand-Gated Ion Channels
- Membrane Protein Biology Tools
- Modulators and Antibodies
- P2X Receptor Modulators
- Proteins and Derivatives
- Aldehydes
- Antagonists
- Bioactive Small Molecules
- Biochemicals and Reagents
- Building Blocks
- C13-C60
- Carbonyl Compounds
- Cell Biology
- Cell Signaling and Neuroscience
- Chemical Synthesis
- Ion Channels
- Neuroscience
- Neurotransmission
- Neurotransmitters
- Organic Building Blocks
- P
- Mol File:
- 192575-19-2.mol
PPADS TETRASODIUM SALT Chemical Properties
- storage temp.
- −20°C
- solubility
- H2O: >10 mg/mL
- form
- solid
- color
- red to orange
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Unstable in Aqueous Solution
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
PPADS TETRASODIUM SALT Usage And Synthesis
Uses
P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.
Uses
PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease.
Uses
PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease .
Definition
ChEBI: Tetrasodium 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate is an organic sodium salt that is the tetrasodium salt of 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid It has a role as a purinergic receptor P2X antagonist. It is an organic sodium salt and an organosulfonate salt. It contains a 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate.
storage
-20°C (desiccate)
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