Basic information Safety Supplier Related

PPADS TETRASODIUM SALT

Basic information Safety Supplier Related

PPADS TETRASODIUM SALT Basic information

Product Name:
PPADS TETRASODIUM SALT
Synonyms:
  • PPADS Tetrasodium
  • PPADS tetrasodium salt, anhydrous
  • PPADS (sodium salt)
  • 4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonate
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT
  • PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA
  • PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
  • PPADS
CAS:
192575-19-2
MF:
C14H10N3Na4O12PS2
MW:
599.3
Product Categories:
  • Adenosines/P2 Nucleotide Receptor - Antagonists
  • Adenosines/P2 Nucleotide Receptors (Purinergics)
  • GPCR Modulators
  • GPCR Proteins
  • Ligand-Gated Ion Channels
  • Membrane Protein Biology Tools
  • Modulators and Antibodies
  • P2X Receptor Modulators
  • Proteins and Derivatives
  • Aldehydes
  • Antagonists
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Carbonyl Compounds
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Chemical Synthesis
  • Ion Channels
  • Neuroscience
  • Neurotransmission
  • Neurotransmitters
  • Organic Building Blocks
  • P
Mol File:
192575-19-2.mol
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PPADS TETRASODIUM SALT Chemical Properties

storage temp. 
−20°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
red to orange
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3

MSDS

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PPADS TETRASODIUM SALT Usage And Synthesis

Uses

PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease .

Uses

P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.

PPADS TETRASODIUM SALTSupplier

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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3B Pharmachem (Wuhan) International Co.,Ltd.
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EMMX Biotechnology LLC
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888-539-0666
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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400-002-6226
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sales@biochemall.cn
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PPADS TETRASODIUM SALT(192575-19-2)Related Product Information