2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Chemical Properties

Melting point:

131-133°

Boiling point:

394.2±21.0 °C(Predicted)

Density 

1.00±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 49 mg/mL (200.51 mM);Ethanol: 49 mg/mL (200.51 mM)

pka

pKa 10.6±0.1(H2O t = 22.0) (Uncertain)

Water Solubility 

Water: Insoluble

CAS DataBase Reference

526-36-3

Safety Information

Toxicity

LD50 oral in mouse: 215mg/kg

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Usage And Synthesis

Uses

Adrenergic (vasoconstrictor).

Uses

Xylometazoline is used for rhinitis, laryngitis, sinusitis, inflammation of antrum of Highmore, and allergic illnesses of the nasal cavity and throat.

Definition

ChEBI: Xylometazoline is an alkylbenzene.

brand name

Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy).

Synthesis

Xylometazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazoline (11.1.40), is also synthesized in a single reaction by cyclocondensation of 4-tert-butyl-2,6- dimethylbenzylcyanide with ethylendiamine [43,44].

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE(526-36-3)Related Product Information

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