19(R)-HYDROXY PROSTAGLANDIN E1 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)

19(R)-HYDROXY PROSTAGLANDIN E1 Usage And Synthesis

Description

19(R)-hydroxy PGE₁ is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP₁ and EP₃ receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC₅₀ of 320 nM for contracting guinea pig ileum, which express EP₁ receptors, and an EC₅₀ of 80 nM for contracting chick ileum, which express EP₃ receptors.

Uses

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.

Definition

ChEBI: 19R-Hydroxy-PGE1 is a prostanoid.

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