CHEMBRDG-BB 9072017 Chemical Properties

Boiling point:

312.8±22.0 °C(Predicted)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.89±0.10(Predicted)

Appearance

Off-white to light yellow Solid

CHEMBRDG-BB 9072017 Usage And Synthesis

Uses

1-(2-Amino-5-methylthiazol-4-yl)ethanone is a useful research intermediate for the preparation of aminothiazoles.

Synthesis

GENERAL METHOD: 4-Bromopentane-2,3-dione (1.79 g, 10.00 mmol) was dissolved in ethanol (50 mL), followed by the addition of thiourea (760 mg, 9.98 mmol). The reaction mixture was stirred at 100 °C for 1 h, after which it was cooled to room temperature. The product was separated by filtration to afford 1-(2-amino-5-methyl-1,3-thiazol-4-yl)ethan-1-one as an off-white solid (1.2 g, 65% yield).LCMS (ESI) analysis showed [M + H]+ = 157.0.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5879 - 5882
[2] Patent: WO2015/52226, 2015, A1. Location in patent: Paragraph 0353
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2760 - 2779

CHEMBRDG-BB 9072017(40353-62-6)Related Product Information

• 1-(1,3-BENZODIOXOL-5-YL)-2-BROMOETHAN-1-ONE
• 2-AMINO-6,6-DIMETHYL-6,7-DIHYDRO-5H-BENZOTHIAZOL-4-ONE
• 1-(5-METHYL-2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOL-4-YL)-1-ETHANONE
• SALOR-INT L149802-1EA
• 2-METHOXYCARBONYLAMINO-4-METHYLSULFANYL-BUTYRIC ACID, 4-(4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-D]THIAZOL-2-YLAMINO)-PHENYL ESTER
• CHEMBRDG-BB 9072017