Glycine, L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl- Chemical Properties

Density 

1.48±0.1 g/cm3(Predicted)

solubility 

Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml

form 

Solid

InChIKey

WCICZXNLSJRZSX-FQTDNSPRNA-N

Glycine, L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl- Usage And Synthesis

Uses

Glycine, L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L- α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tyrosyl-L-leucyl- valyl-L-arginylglycyl-L-arginyl- is an intermediate of Semaglutide. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the treatment of type 2 diabetes.

References

[1] JESPER LAU*. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide[J]. Journal of Medicinal Chemistry, 2015, 58 18: 7370-7380. DOI: 10.1021/acs.jmedchem.5b00726
[2] JINHUA ZHANG. Efficient synthesis of Aib8-Arg34-GLP-1 (7–37) by liquid-phase fragment condensation[J]. Journal of Peptide Science, 2022, 28 9. DOI: 10.1002/psc.3407